Formulation: 50 mM Tris-HCl, pH 7.5, with 200 mM sodium chloride and 20% glycerol
Purity: ≥90%
Formula Weight: 0
Shelf life (days): 365
Notes: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped positive-stranded RNA virus and the causative agent of COVID-19, a primarily respiratory illness characterized by fever, cough, and shortness of breath that can lead to life-threatening complications.{53462,53459,53461,55257,55258} The SARS-CoV-2 genome contains approximately 30 kilobases and 14 open reading frames (ORFs) that encode four structural proteins: spike, envelope, membrane, and nucleocapsid, as well as 16 non-structural proteins and 9 accessory factors.{57176} SARS-CoV-2 non-structural protein 7 (nsp7) is encoded within ORF1ab and is a cofactor in the RNA replication transcriptional complex. nsp7 is highly conserved in coronaviruses, and in SARS-CoV-2 it forms a decameric RNA replication transcriptional complex with the RNA polymerase cofactor nsp8 and the RNA-dependent RNA polymerase (RdRp) nsp12.{72344} Mutations in the nsp7-nps8 binding interface reduce the stability of the RNA replication transcriptional complex, leading to impaired RNA polymerase activity.{72345}
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