Product Type: Inhibitor
CAS No.: 152121-30-7
MolecularFormula: C20H14FN3O
Molecular Weight: 331,3
Source: Synthetic
Purity: ≥98% (TLC)
Solubility: Soluble in methanol, DMSO or acetone; slightly soluble in ethyl acetate
Appearance: Pale yellow solid
PubChem CID: 5353940
Scientific Background: SB202190 is a highly selective and potent inhibitor of p38 MAP kinase. Specifically, it binds within the ATP pocket of the active kinase and selectively inhibits the p38α and β isoforms. It has been shown to induce apoptosis. SB202190 is cell-permeable.
References: 1. Nemoto S., Xiang J., Huang S., & Lin A. (1998) J. Bio. Chem. 273(26): 16415–16420.2. Karahashi H., Nagata K., Ishii K., & Amano F. (2000) Biochimica Et Biophysica Acta. 1502(2): 207–223.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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