Product Type: Inhibitor
CAS No.: 152121-47-6
MolecularFormula: C21H16FN3OS
Molecular Weight: 377,4
Source: Synthetic
Purity: ≥98% (HPLC)
Solubility: Soluble in DMSO (50 mg/ml)
Appearance: White to off-white powder
PubChem CID: 176155
Scientific Background: SB203580 is a a pyridinyl imidazole that inhibits p38 MAP kinase. SB 203580 has also been shown to inhibit heat shock protein 27 (HSP 27) phosphorylation and has been shown to induce the activation of Raf-1. It displays 100-500-fold selectivity over LCK, GSK-3β and PKBα. SB203580 is cell permeable.
References: 1. Hall-Jackson C. A., Goedert M., Hedge P., & Cohen P. (1999) Oncogene. 18(12): 2047–2054.2. Saklatvala, J., et al. (1996) J. Bio. Chem. 271(12): 6586–6589.3. Cuenda A., et al. (1995) FEBS Letters. 364(2): 229–233.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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