SB216763, CAS 280744-09-4

GSK-3 kinase inhibitor

Product Type: Inhibitor

CAS No.: 280744-09-4

MolecularFormula: C19H12Cl2N2O2

Molecular Weight: 371,2

Source: Synthetic

Purity: ≥98% (TLC)

Solubility: Soluble in DMSO (>25 mg/ml)

Appearance: Orange solid

PubChem CID: 176158

Scientific Background: SB216763 is a potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor. It inhibits both human GSK-3α and GSK-3β. SB216763 has been shown to stimulate glycogen synthesis in human liver cells and mimic other actions of insulin. SB216763 is cell-permeable and ATP-competitive.

References: 1. Culbert A.A., et al. (2001) FEBS Letters. 507(3): 288–294.2. Coghlan M.P., et al. (2000) Chem. Biol. 7(10): 793–803.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• SKU: STRSIH-510-5MG
• Manufacturer: Stressmarq Biosciences
• Manufacturer SKU: SIH-510-5MG
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK