Product Type: Inhibitor
CAS No.: 354812-17-2
MolecularFormula: C9H8N2OS2
Molecular Weight: 224,3
Source: Synthetic
Purity: ≥98% (TLC)
Solubility: Soluble in DMSO (>25 mg/ml)
Appearance: Yellow solid
PubChem CID: 2807869
Scientific Background: SC 514 is a selective and reversible inhibitor of IκB kinase 2 / IKKβ (IKK-2). It has been shown to displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK. SC-514 exhibits anti-inflammatory properties. SC 514 is cell permeable.
References: 1. Kishore N., et al. (2003) J. Biol. Chem. 278(35): 32861–32871. 2. Baxter A., et al. (2004) Bioorganic Med. Chem. Letters. 14(11): 2817–2822.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.