SCAF8 Polyclonal Antibody, Rabbit

Abbreviation: SCAF8

Target Synonym: SCAF8;RBM16

Conjugation: Unconjugated

UNIProt ID: Q9UPN6

Background: Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD of the largest RNA polymerase II subunit (POLR2A, and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF4, also acts as a positive regulator of transcript elongation.

Concentration: 1mg/mL

Immunogen: Recombinant fusion protein of human SCAF8

Dilution: WB 1:500-1:1000

• SKU: ELSE-AB-92158-60
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: ELA-E-AB-92158-60
• Green Labware: No
• Package Unit: 60 µl
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine), Rat (Rattus)
• Clonality: Polyclonal
• Application: Western Blotting
• Isotype: IgG
• Host: Rabbit