Senexin C, CAS 2375554-02-0

Product Description: Senexin C is a selective and orally active CDK8/19 inhibitor. Senexin C shows a strong tumor-enrichment pharmacokinetic (PK) profile and tumor-pharmacodynamic (PD) marker responses. Senexin C inhibits the growth of MV4-11 leukemia cells with good tolerability[1].

Applications: Cancer-Kinase/protease

Formula: C28H27N5O

References: [1]Zhang L, et al. A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics. J Med Chem. 2022; 65(4):3420-3433.

CAS Number: 2375554-02-0

Molecular Weight: 449.55

Compound Purity: 98.82

Research Area: Cancer

Solubility: DMSO : 33.33 mg/mL (ultrasonic;warming;adjust pH to 2 with 1M HCl;heat to 160°C)

Target: CDK

• SKU: MEXHY-143889-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-143889-10
• Package Unit: 10 mg
• Quantity Unit: STK