SGC-iMLLT, CAS 2255338-25-9

Formulation: A crystalline solid

Formal Name: 1-methyl-N-[2-[[(2S)-2-methyl-1-pyrrolidinyl]methyl]-1H-benzimidazol-6-yl]-1H-indazole-5-carboxamide

Purity: ≥98%

Formula Markup: C22H24N6O

Formula Weight: 388,5

Shelf life (days): 1460

CAS Number: 2255338-25-9

Notes: SGC-iMLLT is an inhibitor of the YEATS domain-containing proteins MLLT1 and MLLT3.{52195} It binds to the MLLT1 YEATS1 and MLLT3 YEATS3 domains (Kds = 129 and 77 nM, respectively).{52195} It is selective for YEATS1 and -3 over YEATS2 and -4 (IC50s = >10 µM), as well as a panel of 48 bromodomains at 50 µM. SGC-iMLLT inhibits the interaction of histone H3.3 with MLLT3 (IC50 = 400 nM in a reporter assay) and decreases expression of the tumorigenic genes MYC and DDN in MV-4-11 leukemia cells when used at a concentration of 1 µM.

• SKU: CAY28113-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 28113-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK
• Application: GC-MS