Target: SHANK1
Conjugate: Unconjugated
Product Type: Monoclonal
Clone Number: N22/21 (Formerly sold as S22-21)
Immunogen: Fusion protein amino acids 469-691 (SH3/PDZ domains) of rat Shank1
Swiss-Prot: Q9WV48
Purification: Protein G Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects ~190-220 kDa (alternative splice variants). No cross-reactivity against Shank2 or Shank3.
Cellular Localization: Cytoplasm,Cell Junction,Synapse,Postsynaptic Cell Membrane,Postsynaptic Density
Scientific Background: Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (1). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina (2). Other recent studies suggest that the disruption of glutamate receptors at the Shank postsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimer's disease (3).
References: 1. Sheng M., and Kim E. (2000) Journal of Cell Science. 113: 1851-1856.2. Kim J.H., et al. (2009) Exp Mol Med. 41(4): 236-242.3. Gong Y., et al. (2009) Brain Res. 1292: 191-198.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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