Target: SHANK3
Conjugate: FITC
Product Type: Monoclonal
Clone Number: S69
Immunogen: Synthetic peptide amino acids 840-857 of rat Shank3
Swiss-Prot: Q9JLU4
Purification: Protein G Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects ~190kDa. No cross-reactivity against Shank1 or Shank2.
Cellular Localization: Cytoplasm,Cell Junction,Synapse,Postsynaptic Cell Membrane,Postsynaptic Density
Scientific Background: Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (1). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Shank proteins are also crucial in receptor tyrosine kinase signaling; specifically, Shank3 can mediate Erk-MAPK and P13K signaling which is crucial for tubule formation (2). Shank3 is also one of the latest genes to be associated with autism. A mutation of a single copy of Shank3 on chromosome 22q13 can result in language and/or social communication disorders (3).
References: 1. Sheng M., and Kim E. (2000) Journal of Cell Science. 113: 1851-1856.2. Schuetz G., et al. (2004) JCB. 167(5): 645-952.3. Durand C.M., et al. (2007) Nature Genetics. 39: 25-27.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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