Conjugation: HRP: Horseradish Peroxidase
Description of Target: SHB is the adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. SHB may play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. SHB may also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. SHB may also regulate IRS1 and IRS2 signaling in insulin-producing cells.
Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SHB
Key Reference: Kriz,V., (2006) J. Biol. Chem. 281 (45), 34484-34491
Molecular Weight: 55kDa
Peptide Sequence: Synthetic peptide located within the following region:
ERPSQPPQAVPQASSAASASCGPATASCFSASSGSLPDDSGSTSDLIRAYProduct Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Protein Name: SH2 domain-containing adapter protein B
Protein Size: 509
Purification: Affinity Purified
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