Background: Epithelial-mesenchymal transformation is a critical event in the development of many organ systems including heart. Transforming Growth Factor (TGF ) is one of a number of factors that mediates this transformation.Antibodies directed against TGF Type II recepttor block both the endicardial cell activation and subsequent migration that constitute transformation in the chick atrioventricular (AV) cushion.
Positive Control: Recombinant proteins conjugated to OVA, GST, His tags and other. Native TGF beta II proteins.
Immunogen: Protein containing chick transforming growth factor type II receptor a.a.77-148.
Purification Method: Ammonium Sulfate Precipitation
Concentration: See vial for concentration
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide
References: 1) C. Brown, et. al. (1999) Dev. Dynamics, 1-7
UniProt: Q90999 (Chicken)
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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