Background: Activin Receptor-Like Kinase 2 is a member of the superfamily of type I receptors for transforming growth factor- (TGF- ). This receptor binds both activin and bone morphogenic proteins (BMPs). In mice, these receptors are expressed mainly in the extraembryonic visceral endoderm before gastrulation and later in both embryonic and extraembryonic cells during gastrulation. Also, it has been shown that ALK2 associates with and phosphorylates Smad1 and also regulated Smad5 and Smad8 phosphorylation. Additionally, it induces the Tlx2 promoter in the absense of BMP7.
Immunogen: Recombinant protein derived from the extracellular domain of the chicken ALK2 protein. Protein shares significant homology with the mouse, rat and human sequences.
Purification Method: Ammonium Sulfate Precipitation
Concentration: See vial for concentration
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide
References: 1. Lai, Y.T., et al. 'Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation.' Dev. Biol. 2000, 222, 1-11.2. Gu, Z., et al. 'The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo.' Development 1999, 126, 2551-2561.3. Macias-Silva, M., et al. 'Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2.' J. Biol. Chem. 1998, 273, 25628-25636
UniProt: Q90ZK6
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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