Background: Human herpervirus-8 (HHV-8) cyclin is a component of the HHV-8 virus particle. HHV8 has been found to be associated with three different diseases observed in AIDS patients; kaposi's sarcoma, primary effusion lymphoma (which is a rare type of non-Hodgkin lymphoma affecting the body cavities) and multicentric Castleman's disease. To date there is much evidence to support a direct role for HHV8 in kaposi's sarcoma.
Immunogen: Inclusion Bodies from E. Coli expressing his-tagged full length human cyclin G2 protein.
Purification Method: Ammonium Sulfate Precipitation.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: Carbone, A., et al. 'Proliferation in HHV-8-positive primary effusion lymphomas is associated with expression of HHV-8 cyclin but independent of p27(kip1).' Am. J. Pathol. 2000, 156, 1209-1215
Product Specific References:
1. Godfrey, A., et al. 'Inhibiting primary effusion lymphoma by leniviral vectors encoding short hairpin RNA.' Blood, 2005, 105, 2510-2518.
2. Sugaya, M., et al. 'Lymphatic dysfunction in transgenic mice expressing KSHV k-cyclin under the control of the VEGFR-3 promoter.' Blood, 2005, 105, 2356-2363.
3. Jarviluoma, A., et al. 'KSHV viral cyclin binds to p27KIP1 in primary effusion lymphomas.' Blood, 2004, 104, 3349-3354.
UniProt: O40946 (KSHV).
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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