SHP-2 Activating Peptide (IRS1_pY1172(dPEG8)pY1222)

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Background: It has been shown that the bisphosphorylated insulin receptor substrate 1 (IRS-1) binds to the (N)-SH2 domain of SHP2 (PTPN11) resulting in activation of the SHP2 enzymatic activity.

Concentration: 100 µM

Description: IRS1_pY1172(dPEG8)pY1222(SEQ: H2N-LN(pY)IDLDLV(dPEG8)LST(pY) -ASINFQK-amide)

Formulation: 100 μM peptide in DMSO

Purity: >95% (by HPLC)

Storage Stability: Soluble in DMSO. Store at -20°C.

Biosafety Level: Not applicable (BSL-1)

References: Chen Y-N et al., Nature, 535(7610):148-152 (2016)

• SKU: BPS79319-2
• Manufacturer: BPS Bioscience
• Manufacturer SKU: 79319-2
• Green Labware: No
• Package Unit: 100 µl
• Quantity Unit: STK