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Encompassing Amino Acids: 2-382(end)
Background: Sialidases are glycosyl hydrolases that cleave the α-ketosidic bond from sialic acid residues. These proteins are crucial for microbes like Salmonella to successfully infect their hosts by degrading the cell ʹs glycans and contributing to adherence and infection. Salmonella typhimurium infection results in salmonellosis, characterized by gastrointestinal symptoms, such as abdominal cramps and diarrhea, which last from 4 to 7 days. It can, however, result in severe cases requiring hospitalization. Inhibitors targeting sialidases may prove useful in the treatment of bacterial infections.
Description: Recombinant Salmonella typhimurium sialidase, also known as NANH (N-acylneuraminate glycohydrolase), full length encompassing amino acids 2-382. The construct contains an N-terminal His-tag (6xHis). This protein was affinity purified.
Format: Aqueous buffer solution.
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Genbank: AE006468.2
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal His-Tag
Uniprot: P29768
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
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