Sirtinol, CAS 410536-97-9

SIRT inhibitor

Product Type: Inhibitor

CAS No.: 410536-97-9

MolecularFormula: C26H22N2O2

Molecular Weight: 394,47

Source: Synthetic

Purity: >98%

Solubility: Soluble to 100 mM in DMSO

Appearance: Off-white to yellow crystals

PubChem CID: 5717148

Scientific Background: Cell-permeable, selective sirtuin deacetylase inhibitor (IC50 values are 38, 68 and 131 µM at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro.

References: 1. Grozinger CM., et al (2001) J.Biol.Chem. 276: 38837. 2. Mai A., et al (2005) J.Med.Chem. 48: 7789. 3. Kahyo T., et al (2008) J.Pharmacol.Sci. 108: 364.4. Jung-Hynes B., et al (2009) J.Biol.Chem. 284: 3823.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• SKU: STRSIH-360-5MG
• Manufacturer: Stressmarq Biosciences
• Manufacturer SKU: SIH-360-5MG
• Package Unit: 5 mg
• Quantity Unit: STK