Abbreviation: SLC8A1
Target Synonym: SLC8A1;NCX1
Conjugation: Unconjugated
UNIProt ID: P32418
Background: In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human SLC8A1
Dilution: WB 1:1000-1:2000,IHC 1:50-1:200
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