SLM6031434 (hydrochloride), CAS 1897379-34-8

Formulation: A crystalline solid

Formal Name: (2S)-2-[3-[4-(octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-pyrrolidinecarboximidamide, monohydrochloride

Purity: ≥98%

Formula Markup: C22H30F3N5O2 • HCl

Formula Weight: 490

Shelf life (days): 730

CAS Number: 1897379-34-8

Notes: SLM6031434 is an inhibitor of sphingosine kinase 2 (SPHK2) (Ki = 0.4 μM for the recombinant mouse enzyme).{38413} It is selective for SPHK2 over SPHK1 (Kis = >20 μM). It decreases sphingosine-1-phosphate (S1P; Item No. 62570) and increases sphingosine levels in U937 monocytic leukemia cells in a concentration-dependent manner. SLM6031434 (5 mg/kg) reduces blood S1P levels in Sphk1-/-, but not Sphk2-/-, mice. SLM6031434 also increases blood S1P levels in wild-type mice and rats.

• SKU: CAY30434-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 30434-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK
• Application: Reinstoffe