Formulation: A solid
Formal Name: 4-ethyl-11-(ethyl-2,2,2-d3)-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C22H17D3N2O5
Formula Weight: 395,4
Shelf life (days): 1460
CAS Number: 718612-49-8
Notes: SN-38-d3 is intended for use as an internal standard for the quantification of SN-38 (Item No. 15632) by GC- or LC-MS. SN-38 is an inhibitor of topoisomerase I and an active metabolite of the prodrug irinotecan (Item No. 14180).{22662,51556} It is formed from irinotecan by carboxylesterases.{22662} SN-38 (0.1, 1, and 10 µM) induces topoisomerase I-dependent DNA cleavage in a cell-free assay.{51556} It induces DNA single-strand breaks in HT-29 colorectal adenocarcinoma cells when used at a concentration of 200 nM and cytotoxicity in HT-29 cells (IC50 = 8.8 nM). SN-38 (100 mg/kg per day) reduces tumor volume without affecting body weight in an MX-1 breast cancer mouse xenograft model.{51555}
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