Target: SLC38A1
Conjugate: HRP
Product Type: Monoclonal
Clone Number: N104/32 (Formerly sold as S104-32)
Immunogen: Fusion protein amino acids 1- 63 of rat SNAT1
Swiss-Prot: Q9JM15
Purification: Protein G Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects ~50kDa.
Cellular Localization: Cell Membrane
Scientific Background: The sodium-coupled neutral amino acid transporters (SNAT) of the SLC38 gene family include System A subtypes SNAT1, SNAT2 and SNAT4 and System N subtypes SNAT3 and SNAT5. The SLC38 transporters are essential for the uptake of nutrients, energy production, metabolism, detoxification, and the cycling of neurotransmitters. The SNAT1 protein, also designated ATA1 or NAT2 is encoded by the human gene SLC38A1 which maps to chromosome 12q13.11. SNAT1 is responsible for the transport of glutamine, an intermediate in the synthesis of urea, and may be involved in the generation of glutamate in the retina. SNAT1 protein may be detected in some tissues such as heart, brain and placenta and expression levels are enriched in certain neuronal populations within the CNS. SNAT1 is not present in astrocytes.
References: 1. Hatanaka T., et al. ( 2000) Biochim. Biophys. Acta 1467: 1-6.2. Wang H., et al. (2000) Biochem. Biophys. Res. Commun. 273: 1175-1179.3. Gu S., et al. (2001) J. Biol. Chem. 276: 24137-24144.4. Freeman T.L., et al. (2002) Arch. Biochem. Biophys. 400: 215-222.5. Palii S.S., et al. (2004) J. Biol. Chem. 279: 3463-3471.6. Sidoryk M., et al. (2004) Neuroreport. 15: 575-578. Erratum in: 2004. Neuroreport. 15: 533.7. Desforges,M., et al. (2006) Am. J. Physiol. Cell. Physiol. 290: 305-312.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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