Target: Sodium Iodide Symporter
Conjugate: Biotin
Product Type: Monoclonal
Clone Number: FP5
Immunogen: Mannose binding protein and human NIS fusion (AA468-643)
Swiss-Prot: Q92911
Purification: Protein G Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects ~97kDa, non-glycosylated version at 68kDa. Other minor bands associated with hNIS at 160kDa, and degradation products at ~30 kDa, and ~15kDa.
Cellular Localization: Membrane
Scientific Background: The sodium iodide symporter (NIS) is an ion pump that actively transports iodide across the basolateral membrane into thyroid epithelial cells (1, 2). This is important step in the process of iodide organificaton and the formation of triiodothyronine and thyroxine (3).
References: 1. Dai G., Levy O., Carrasco N. (1996) Nature. 379(6564): 458-460.2. Snabik P.A., et al. (1997) Endocrin. 138(8): 3555-3558.3. Dohan O., et al. (2007) Proc Natl Acad Sci USA. 104(51): 20250-20255.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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