Abbreviation: SOX-2
Target Synonym: ANOP3,cb236,Delta EF2a,lcc,MCOPS3,MGC148683,MGC2413,RGD1565646,Sex determining region Y box 2,SOX 2,Sox2,SOX2,SRY (sex determining region Y) box 2,SRY box containing gene 2,SRY related HMG box 2,SRY related HMG box gene 2,SRY-box 2,Transcription factor SOX 2,Transcription factor SOX-2,ysb
Conjugation: Unconjugated
Clone NO.: YN02195r
UNIProt ID: P48431
Background: The SOX2 gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors, which plays an important role in early organ development. SOX2 can be used in the auxiliary diagnosis of germ cell tumors. 90% of embryonic cancers express SOX2, but not in seminoma, yolk sac tumor and choriocarcinoma. SOX2 has been shown to be a negative prognostic factor and associated with aggressive phenotypes in breast, head and neck, gastric, colorectal and bladder cancers. In small cell lung cancers, SOX2 was also correlated with a poor prognosis. Conversely, SOX2 is expressed in a high percentage of lung squamous cell carcinomas and was shown to be an independent positive prognostic marker.
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