Spautin-1, CAS 1262888-28-7

Autophagy inhibitor

Product Type: Inhibitor

CAS No.: 1262888-28-7

MolecularFormula: C15H11F2N3

Molecular Weight: 271,26

Source: Synthetic

Purity: ≥98% (TLC); NMR (Conforms)

Solubility: May be dissolved in DMSO (50mg/mL); or ethanol (15mg/mL, warm)

Appearance: White to beige powder.

PubChem CID: 51037431

Scientific Background: Spautin-1 inhibits the deubiquitination activity of USP10 and USP13, two ubiquitin-specific peptidases. This results in the degradation of class III PI3 kinase complexes. Because this group of kinases regulates autophagy, Spautin-1 in turn inhibits autophagy.

References: 1. Liu J., et al. (2011) Cell. 147(1): 223-34.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• SKU: STRSIH-404-5MG
• Manufacturer: Stressmarq Biosciences
• Manufacturer SKU: SIH-404-5MG
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK