Description: Spectrin is an actin binding protein that is a major component of the plasma membrane skeleton. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Vertebrate spectrins have two alpha-subunits (alpha-I/alpha-II) four beta-subunits (beta-I-beta-IV) and a beta-H subunit creating diversity and specialization of function. Spectrin III is highly expressed in brain, kidney, pancreas and liver, and at lower levels in lung and placenta. Spectrin beta 3 is primarily expressed in nervous tissues with highest expression levels in the cerebellum, where it is found in Purkinje cell soma and dendrites. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Conjugate: Purified, with BSA
Concentration: 0.2 mg/mL
Storage buffer: PBS, 0.05% BSA, 0.05% azide
Product Origin: Animal - Oryctolagus cuniculus (domestic rabbit), Bos taurus (bovine)
Clone: SPTBN2/2887R
Entrez Gene ID: 6712
Immunogen: Recombinant human SPTBN2 fragment (aa356-475) (exact sequence is proprietary)
Verified AB Applications: Flow (intracellular) (verified)/IF (verified)/WB (verified)
Z-Antibody Applications: Flow, intracellular (verified)/IF (verified)/WB (verified)
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