Background: Sphingosine 1-phosphate (S1P) is a highly bioactive lipid that has a myriad of biological effects both intracellularly as a second messenger and extracellularly by binding to the S1P(1-5)/G-protein-coupled receptors of the endothelial differentiation gene family. Intracellularly, at least two enzymes, sphingosine kinase (1 and 2) and S1P phosphatase, regulate the activity of S1P by governing the phosphorylation of S1P. Regulation of hS1Pase1 with the resultant changes in cellular and secreted S1P has important implications in cell proliferation, angiogenesis and apoptosis.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Mechtcheriakova D, et al. Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses. Cell Signal. 2007 Apr;19(4):748-60. Epub 2006 Sep 30. Links
2. Grey, A., et al. 'Osteoblastic Cells Express Phospholipid Receptors and Phosphatases and Proliferate in Response to Sphingosine 1-Phosphate.' Calcid Tissue Int. 2004
3. Pettus, B.J., et al. 'The sphingosine kinase 1/sphingosine 1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha.' FASEB J. 2003, 17, 1411-1421
4. Johnson, K.R., et al. 'Role of human sphingosine 1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine 1-phosphate levels and cell viability.' J. Biol. Chem. 2003, 278, 34541-34547
5. Cuvillier, O. 'Sphingosine in apoptosis signalling.' Biochim. Biophys. Acta 2002, 1585, 153-162
6. Ogawa, C., et al. 'Identification and characterization of a novel human sphingosine 1-phosphate phosphohydrolase, hSPP2.' J. Biol. Chem. 2003, 278, 1268-1272
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UniProt: Q9BX95.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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