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Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Background: SPHK1 is a lipid enzyme that catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP). It has been implicated in tumor progression through cell proliferation and motility. High levels of SPHK1 have been associated with increased mortality in various forms of human cancer.
Description: The SPHK1 Assay Kit is designed to measure SPHK1 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
Storage Stability: Up to 6 months when stored as recommended.
Supplied As: The SPHK1 Assay Kit comes in a convenient 96-well format, with enough purified SPHK1, Sphingosine, ATP, and kinase assay buffer for 96 enzyme reactions.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Shida, D., et al. 2008. "Targeting SphK1 as a new strategy against cancer." Current Drug Targets 9(8): 662-673.
2. Xia, J., et al. 2012. "miR-124 inhibits cell proliferation in gastric cancer through down-regulation of SPHK1." The Journal of Pathology 227(4): 470-480.
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