Spike S1 Neutralizing Antibody (B.1.617.2, B.1.617.2.1, B.1.1.7, B.1.351, B.1.429, and P.1 Variants) (Clone C-A11) (SARS-CoV-2)

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Applications: The rabbit monoclonal neutralizing IgG can be used for functional assays testing inhibitors against SARS-CoV-2 Spike protein and ACE2 binding.

Assay Conditions: Experimental design and assay protocol for measuring neutralizing antibody's functional activity using BPS Spike S1 (B.1.1.7 Variant) (SARS-CoV-2): ACE2 Inhibitor Screening Colorimetric Assay Kit (BPS Bioscience, #78155).

Clone Number: clone C-A11

Cross Reactivity: This antibody not been tested for cross reactivity with other SARS-CoV-2 variants.

Description: This purified rabbit monoclonal antibody recognizes recombinant wildtype SARS-CoV-2 Spike RBD and trimeric spike proteins. Additionally, this antibody cross-reacts with the B.1.1.7 variant, originally discovered in the U.K, and the B.1.351 variant, originally discovered in South Africa, for both the Spike RBD and trimeric proteins. This neutralizing antibody impedes the interaction between SARS-CoV-2 spike proteins and ACE2 receptor. ACE2 receptor is known to mediate COVID-19 infection through direct binding of the SARS-CoV2 Spike protein. This neutralizing antibody has been functionally tested using BPS Bioscience Spike RBD: ACE2 Inhibitor Screening Kits (BPS Bioscience, #78018, #78133, #78152). This antibody not been tested for cross reactivity with other SARS-CoV-2 variants.

Format: Aqueous buffer solution

Formulation: PBS, 50% glycerol

Genbank: MN908947

Purification: Protein A affinity chromatography

Storage Stability: At least 6 months at +4°C.

Uniprot: P0DTC2

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

• SKU: BPS101024
• Manufacturer: BPS Bioscience
• Manufacturer SKU: 101024
• Green Labware: No
• Package Unit: 100 µg
• Quantity Unit: STK
• Clonality: Monoclonal
• Isotype: Rabbit Monoclonal IgG