Formulation: A solid
Formal Name: 3,3-di(methyl-d3)-butanoic acid-4,4,4-d3, 2-oxo-3-(2,4,6-trimethylphenyl)-1-oxaspiro[4.4]non-3-en-4-yl ester
Purity: ≥99% deuterated forms (d1-d9)
Formula Markup: C23H21D9O4
Formula Weight: 379,5
Shelf life (days): 1460
CAS Number: 2470126-90-8
Notes: Spiromesifen-d9 is intended for use as an internal standard for the quantification of spiromesifen (Item No. 25822) by GC- or LC-MS. Spiromesifen is an insecticide and acaricide that reduces lipid biosynthesis via inhibition of acetyl-CoA carboxylase.{43346,43347} It inhibits chitinase from Egyptian cotton leafworm (S. littoralis) larvae (IC50s = 0.60 and 0.72 μM for enzyme isolated from lab and field strains, respectively).{43348} It induces toxicity in whitefly (T. vaporariorum) nymphs (LC50 = 0.61 mg/L), spider mite (T. cinnabarinus) eggs (LC50 = 0.16 mg/kg), and second instar larvae of S. littoralis lab and field strains (LC50s = 0.44 and 0.68 ppm, respectively, at 72 hours post-application).{43346,43347,43348} Spiromesifen (600 mg/kg) also induces 50, 60, and 70% mortality in the Lepidoptera pests H. armigera, O. nubialis, and P. xylostella, respectively, and induces 100% mortality in M. separata when used at a dose of 100 mg/kg.{43347} It induces toxicity in D. magna (EC50 = >0.092 mg a.s./L) and the fish species O. mykiss and L. macrochirus (LC50s = 0.016 and >0.034 mg a.s./L, respectively) but not rats (LD50 = >2,000 mg/kg).{43350} Spiromesifen also inhibits the human GST isozyme GSTA1-1 (IC50 = 12.1 μM).{43349} Formulations containing spiromesifen have been used as insecticides and miticides in agriculture, as well as commercial, industrial, and residential areas.
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