SRI-41315, CAS 1613509-49-1

Product Description: SRI-41315 induces a prolonged pause at stop codons and suppresses PTCs (premature termination codons) associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells, restoring CFTR (cystic fibrosis transmembrane conductance regulator) expression and function. SRI-41315 suppresses PTCs by reducing the abundance of the termination factor eRF1. SRI-41315 also potentiates aminoglycoside-mediated readthrough, leading to synergistic increases in CFTR activity[1].

Applications: COVID-19-immunoregulation

Formula: C22H19N3O2

References: [1]Sharma J, et al. A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion. Nat Commun. 2021 Jul 16;12(1):4358.

CAS Number: 1613509-49-1

Molecular Weight: 357.41

Compound Purity: 99.94

Research Area: Inflammation/Immunology

Solubility: DMSO : 20.83 mg/mL (ultrasonic)

Target: CFTR

• SKU: MEXHY-150090-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-150090-10
• Package Unit: 10 mg
• Quantity Unit: STK