Scientific Background: STF-62247 is a selective cell-permeable inducer of autophagy. This is demonstrated by an induction of large vacuole formation in cells. This observation is especially pronounced in von Hippel-Lindau deficient renal carcinoma cells. Induction of autophagy is also seen in vivo in mice.
References: 1. Turcotte S., et al. (2008) Autophagy, 4(7): b944-6.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.