Product Type: Inhibitor
CAS No.: 52029-86-4
MolecularFormula: C21H14N2O5
Molecular Weight: 374,3
Source: Synthetic
Purity: ≥98% (TLC)
Solubility: Soluble in DMSO (10 mg/ml)
Appearance: Yellow solid
PubChem CID: 16760660
Scientific Background: STO 609 is a potent, competitive and selective inhibitor of Ca2+/Calmodulin-dependent protein kinase kinase (CaM-KK). STO 609 has been shown to bind to the CaMKK catalytic domain, consequently inhibiting autophosphorylation. It is a valuable tool for exploring the role of the CaM-KK pathway in various physiological processes. STO 609 is cell-permeable.
References: 1. Tokumitsu, H., et al. (2002) J. Biol. Chem. 277(18): 15813–15818. 2. Levine Y.C., Li G.K., & Michel T. (2007) J. Biol. Chem. 282(28): 20351–20364. 3. Anderson K.A., et al. (2008) Cell Metabolism. 7(5): 377–388.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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