Application Note: Anti-Synapsin I antibody has been tested in Western Blotting. Expect ~78kDa. Specific conditions for reactivity should be optimized by the end user.
Concentration Value: Titrated value sufficient to run approximately 10 mini blots.
Western Blot Dilution: 1:1000
General Disclaimer Note: This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
Immunogen: Anti-Synapsin I Antibody was produced in rabbit by repeated immunizations with native bovine synapsin I protein purified from bovine brain.
Physical State: Liquid
Purity and Specificity: Anti-Synapsin I antibody was prepared from monospecific neat serum. This antibody is directed against bovine synapsin I. Anti-Synapsin I is specific for the ~78kDa synapsin I protein doublet. Immunolabeling blocked by preadsorption of the antibody with the protein used to generate the antibody. Reactivity is reported against human, mouse and rat.
Background: Synapsin I plays a key role in synaptic plasticity in the brain (Feng et al., 2002; Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. In addition to its role in plasticity, the expression of synapsin I is a precise indicator of synapse formation. Thus, Synapsin I immunocytochemistry provides a valuable tool for the study of synaptogenesis. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation. Anti-Synapsin I Antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.
Low Endotoxin: No
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