Conjugation: FITC: Fluorescein Isothiocyanate
Description of Target: Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. TAF1C is the largest SL1-specific TAF. Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.
Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TAF1C
Key Reference: Friedrich,J.K., (2005) J. Biol. Chem. 280 (33), 29551-29558
Molecular Weight: 95kDa
Peptide Sequence: Synthetic peptide located within the following region:
MDFPSSLRPALFLTGPLGLSDVPDLSFMCSWRDALTLPEAQPQNSENGALProduct Format: Liquid. Purified antibody supplied in 1x PBS buffer.
Protein Name: TATA box-binding protein-associated factor RNA polymerase I subunit C
Protein Size: 869
Purification: Affinity Purified
Subunit: C
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