Abbreviation: TAK1
Target Synonym: CSCF;FMD2;MEKK7;TAK1;TGF1a;MAP3K7
Conjugation: Unconjugated
UNIProt ID: O43318
Background: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human TAK1
Dilution: WB 1:500-1:2000,IHC 1:50-1:200,IF 1:50-1:200
English
Deutsch
