Formulation: A solid
Formal Name: N-[2-[(7S,8S)-3-carboxy-7-(2-carboxyethyl)-13-ethenyl-18-ethyl-7,8-dihydro-2,8,12,17-tetramethyl-21H,23H-porphin-5-yl]acetyl]-L-aspartic acid, tetrasodium salt
Purity: ≥95%
Formula Markup: C38H37N5O9 • 4Na
Formula Weight: 799,7
Shelf life (days): 1460
CAS Number: 220201-34-3
Notes: Talaporfin is a photosensitizer.{39227} It induces apoptosis, DNA double-strand breaks (DSBs), and the production of reactive oxygen species (ROS) in TE-11R 5-fluorouracil-resistant esophageal squamous cell carcinoma (ESCC) cells when used at a concentration of 30 µg/ml in combination with radiation.{58914} Talaporfin (2.5, 5, and 10 mg/kg) in combination with photodynamic therapy (PDT) reduces tumor growth in a TE-11R ESCC mouse xenograft model. Formulations containing talaporfin have been used as photosensitizers in PDT for the treatment of endobronchial cancer.
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