Product Type: Inducer
CAS No.: 54965-24-1
MolecularFormula: C26H29NO•C6H8O7
Molecular Weight: 563,65
Source: Synthetic
Purity: ≥99%
Solubility: Soluble in methanol (50 mg/ml) or ethanol; very slightly soluble in water or acetone.
Appearance: White to off-white powder
PubChem CID: 2733525
Scientific Background: Tamoxifen citrate is an endocrine therapy drug used to treat breast cancer. It acts to interrupt estrogen signaling by blocking the estrogen receptor (ER). In vivo, tamoxifen and tamoxafin metabolites bind to estrogen receptors, causing the transcription of estrogen-response genes to be inhibited. In vitro, Tamoxifen is known to inhibit protein kinase C through estrogen receptor-independent antineoplastic effects. This drug therefore has important applications in breast cancer research, particularly in ER+ breast cancers. Recent studies have shown tamoxifen-resistant cells use autophagy as a survival mechanism.
References: 1. Thomas, S. et al. (2011). Breast Cancer Res Treat, 130(2): 437-47.2. Ma, J. et al. (2014). BMC Cancer, 14: 172.3. Patel, S. et al. (2012). Int J Radiat Oncol Biol Phys, 82(2): 739-42.4. Wang, D. et al. (2004). Mol Endocrinol. 402-11.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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