Target: Stargazin
Conjugate: Unconjugated
Product Type: Monoclonal
Clone Number: N245/36 (Formerly sold as S245-36)
Immunogen: Fusion protein amino acids 203-323 (Cytoplasmic C-terminus) of rat TARPGamma2
Swiss-Prot: Q71RJ2
Purification: Protein G Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects ~35-55kDa. Does not cross-react with TARPGamma3.
Cellular Localization: Membrane
Scientific Background: Stargazin belongs to a group called voltage gated calcium channels (VGCCs) which are present in most excitable cells. Stargazin is thought to stabilize the calcium channel in an inactivated (closed) state. There are five high voltage activated calcium channel types (L, N, P, Q, and R) and one low voltage activated channel type (T). Each of these channels exists as a heteromultimer of a1, b, a2/ d and g subunits with the voltage activated calcium channel function carried by the a subunits. VGCCs exert spatial and temporal control over cellular calcium concentrations and serve to modulate neurotransmitter release, hormone secretion, muscle contraction, electrical activity, cell metabolism and proliferation, gene expression, and neuronal survival.
References: 1. Gill M.B., et al. (2011) J Neurosci. 31(18): 6928-6938.2. Yu L. (2011) Neuroscience. 178: 13-20.3. Steinmetz C.C., Turrigiano G.G. (2010) J Neurosci. 30: 14685-14690.4. Kato. A.S. et al. (2007) J Neurosci. 27: 4969-4977.5. Letts V.A., et al. (1998) Nat Genet. 19: 340-34
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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