Product Type: Inducer
CAS No.: 33069-62-4
MolecularFormula: C47H51NO14
Molecular Weight: 853,9
Source: Synthetic
Purity: >98% (TLC); NMR (Conforms)
Solubility: Soluble in DMSO, ethanol or acetonitrile
Appearance: White solid
PubChem CID: 36314
Scientific Background: Paclitaxel is a mitotic inhibitor that promotes and stabilizes tubulin polymerization, causing cell cycle arrest (1). Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering apoptosis (2).
References: 1. Wani M., Taylor H., Wall M., Coggon P., and McPhail A. (1971) J Am Chem Soc. 93(9): 2325-2327.2. Park S.J., et al. (2004) J Biol Chem. 279(49): 51057-51067.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.