Clone Name: MT517
Application Note: *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 44
Specificity/Sensitivity: This antibody is able to detect native and recombinant human latent Transforming Growth Factor-β1 (TGF-β1), binds to the Latency Associated Protein (LAP), which is a part of the latent TGF-β1 complex and does not bind to latent TGF-β2 or -β3.
Form: Liquid
Buffer (with preservative): PBS, 0.02% Sodium azide.
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016]
Uniprot ID: P01137
Antigen Species: Human
Immunogen: Recombinant latent TGF-β1
Purification: Protein G purified
Conjugation: Biotin
Full Name: transforming growth factor beta 1
English
Deutsch
