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Applications: Study enzyme kinetics and screen small molecule inhibitors for drug discovery and high throughput (HTS) applications.
Background: The transforming growth factor beta (TGFB) signaling pathway regulates a wide range of biological and cellular processes including cell growth, differentiation, survival/apoptosis, and migration. TGFβ binds to a type II receptor dimer, which recruits a type I receptor dimer forming a hetero-tetrameric complex. The TGFβ receptor is a transmembrane serine/threonine kinase that phosphorylates proteins of the SMAD (Mothers against decapentaplegic homolog) family. Due to its role in immunosuppression, cancer, and inflammatory diseases, among others, this receptor is an attractive therapeutic target.
Contraindications: The final concentration of DMSO in the assay should not exceed 1%.
Description: The transforming growth factor beta receptor (TGFβR1, also known as ALK5) Kinase Assay Kit is designed to measure the serine/threonine activity of TGFβR1 (ALK5) for screening and profiling applications using ADP-Glo® as a detection reagent.
Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed.
Supplied As: The assay kit comes in a convenient 96-well format, with enough purified recombinant TGFβR1 (ALK5) kinase, kinase substrate, ATP, and kinase assay buffer for 100 enzyme reactions.
Uniprot: P36897
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
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