Thalidomide, CAS 50-35-1

E3 UB ligase inhibitor

Product Type: Inhibitor

CAS No.: 50-35-1

MolecularFormula: C13H10N2O4

Molecular Weight: 258,2

Source: Synthetic

Purity: >98%

Solubility: Soluble in 5 mg/ml DMSO

Appearance: White Solid

PubChem CID: 5426

Scientific Background: Binds to the E3 ubiquitin ligase complex formed between CRBN, DDB1 and Cul4A inhibiting ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Cell permeable. Caution: Teratogenic.

References: 1. Ito T., et al. (2010) Science. 327:1345.2. Weglicki W.B., et al. (1993) Mol. Cell. Biochem. 129:195.3. D'Amato R.J., et al. (1994) Proc. Natl. Acad. Sci. USA. 91:4082.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• SKU: STRSIH-336-100MG
• Manufacturer: Stressmarq Biosciences
• Manufacturer SKU: SIH-336-100MG
• Package Unit: 100 mg
• Quantity Unit: STK