Thioredoxin 1 (mouse) Polyclonal Antibody

Thioredoxin 1 (mouse) Polyclonal Antibody
SKU
CAY11540-100
Packaging Unit
1 ea (100 µg)
Manufacturer
Cayman Chemical

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Formulation: 100 µg of affinity-purified polyclonal antibody

Immunogen: Mouse Trx1

Shelf life (days): 1095

Notes: Thioredoxin 1 (Trx1) is a thiol-disulfide oxidoreductase and part of the antioxidant thioredoxin system that is involved in the maintenance of cellular thiol redox homeostasis.{57135,57136,57138} It is ubiquitously expressed, localizes primarily to the cytoplasm with some nuclear localization, and is upregulated in and released from cells under conditions of oxidative stress.{57135,57137,57136} Trx1 contains two active site cysteine residues at positions 32 and 35, with additional cysteines at positions 62, 69, and 73.{57136} During the catalytic cycle, the active site cysteines are oxidized to a disulfide upon reduction of oxidized protein disulfide substrates and are subsequently restored to their reduced state by thioredoxin reductase (TrxR) and NADPH.{57135,57136} It regulates redox-sensitive transcription factors including NF-κB, p53, and the glucocorticoid receptor, as well as inhibits apoptosis through redox-sensitive binding and regulation of apoptosis signal-regulating kinase 1 (ASK1).{57137,57136} Homozygous disruption of the gene encoding Trx1, Txn1, is embryonic lethal in mice.{52683,57135} Cayman's Thioredoxin 1 (mouse) Polyclonal Antibody can be used for Western blot (WB) applications.
More Information
SKU CAY11540-100
Manufacturer Cayman Chemical
Manufacturer SKU 11540-100
Package Unit 1 ea (100 µg)
Quantity Unit STK
Reactivity Mouse (Murine)
Clonality Polyclonal
Application Western Blotting
Host Rabbit
Conjugate Unconjugated
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