Tie2 Kinase Inhibitor, CAS 948557-43-5

Formulation: A crystalline solid

Formal Name: 4-[4-(6-methoxy-2-naphthalenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]-pyridine

Purity: ≥95%

Formula Markup: C26H21N3O2S

Formula Weight: 439,5

Shelf life (days): 1460

CAS Number: 948557-43-5

Notes: Tunica interna endothelial cell kinase 2 (Tie2, also known as angiopoietin-1 receptor or tek) is an endothelium-specific receptor tyrosine kinase important for the development of embryonic vasculature and for angiogenesis and vascular maintenance in adult tissues.{10075} Tie2 kinase inhibitor reversibly and selectively blocks Tie2 kinase activity with an IC50 value of 250 nM.{29691} It is 200-fold more potent for inhibition of Tie2 compared to p38.{29691} Tie2 kinase inhibitor has been shown to reduce angiogenesis in a Matrigel neovascularization assay and to delay tumor growth in MOPC-315 plasmacytoma and SVR angiosarcoma xenograft models.{29691,29690}

• SKU: CAY17858-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 17858-1
• Package Unit: 1 mg
• Quantity Unit: STK