Formulation: A solid
Formal Name: (6S,9R,14R,17S,19aS,25S,27aS,33S,35aS)-N-((S)-1-amino-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl)-9-((S)-2-amino-3-(1H-indol-3-yl)propanamido)-6,25,33-tris(4-aminobutyl)-17-(3-guanidinopropyl)-5,8,16,19,24,27,32,35-octaoxodotriacontahydro-13H-tripyrrolo[2,1-j:2',1'-p:2'',1''-v][1,2]dithia[5,8,11,14,17,20,23,26]octaazacyclononacosine-14-carboxamide, trifluoroacetate salt
Purity: ≥98%
Formula Markup: C62H97N21O11S2 • XCF3COOH
Formula Weight: 1376,7
Shelf life (days): 1460
Notes: Tiger17 is a cyclic peptide and derivative of tigerinin-RC1 and tigerinin-RC2, which are antimicrobial peptides found in crab-eating frog (F. cancrivora) skin secretions.{51495} It increases the proliferation of HaCaT keratinocytes and human skin fibroblasts when used at concentrations ranging from 5 to 20 µg/ml and increases HaCaT cell migration at 20 µg/ml. Tiger17 increases the recruitment of, and the secretion of TGF-β1 and IL-6 from, RAW 264.7 macrophages. Topical application of tiger17 (20 µg/ml) increases the rate of wound closure and re-epithelialization in a mouse model of full-thickness dermal wounds.
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