TIGIT antibody (1G9) (PE)

TIGIT antibody (1G9) (PE)
SKU
GTX01496-08-100
Packaging Unit
100 μg
Manufacturer
GeneTex

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Clone Name: 1G9

Light Chain: Kappa

Product Description: The 1G9 antibody reacts with mouse TIGIT (T cell Ig and ITIM domain), a 26 kDa member of the CD28 receptor family which is reported to regulate T cell receptor (TCR) activation. Within the CD28 family of receptors there are those which have co-stimulatory activity, such as CD28 and CTLA-4, as well as more recently identified receptors like TIGIT which are proposed to provide co-inhibitory signals. TIGIT is expressed and upregulated on activated T cells, and is also expressed on memory and regulatory T cells. Upon engagement by its ligands, CD112 and CD155, TIGIT signaling inhibits T cell proliferation and suppresses T cell responses, without triggering cell deletion. A second inhibitory effect of TIGIT signaling is the generation of immunoregulatory dendritic cells, which secrete IL-10 and TGF-beta to further inhibit T cell function.The 1G9 antibody may be used for flow cytometric analysis of TIGIT, which is expressed at very high levels on T regulatory cells (Tregs) and activated conventional T cells, as well as memory T cells and NK cells.

Application Note: *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Form: Liquid

Buffer (with preservative): 10mM NaH₂PO₄, 150mM NaCl, 0.1% Gelatin, 0.09% Sodium azide.

Concentration: 0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Purification: Purified by affinity chromatography

Conjugation: PE

Full Name: T cell immunoreceptor with Ig and ITIM domains
More Information
SKU GTX01496-08-100
Manufacturer GeneTex
Manufacturer SKU GTX01496-08-100
Green Labware No
Package Unit 100 μg
Quantity Unit STK
Reactivity Mouse (Murine)
Clonality Monoclonal
Application Flow Cytometry
Isotype IgG1
Human Gene ID 100043314
Host Mouse
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