TL12-186, CAS 2250025-88-6

Formulation: A solid

Formal Name: N-[2-[2-[2-[4-[4-[[5-chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]phenyl]-1-piperazinyl]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-acetamide

Purity: ≥95%

Formula Markup: C44H51ClN10O9S

Formula Weight: 931,5

Shelf life (days): 1460

CAS Number: 2250025-88-6

Notes: TL12-186 is a proteolysis-targeting chimera (PROTAC) containing a multi-kinase inhibitor linked to a cereblon (CRBN) binding moiety.{66812} It binds to CRBN (IC50 = 12 nM) and inhibits 193 kinases by greater than 90% in cell-free assays. TL12-186 (1-10,000 nM) inhibits the proliferation of wild-type CRBN-expressing but not CRBN-/- MOLM-14 and MOLT-4 cells.

• SKU: CAY40970-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 40970-50
• Package Unit: 50 mg
• Quantity Unit: STK