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Background: TNF-like ligand 1A (TL1A, also known as Vascular endothelial growth inhibitor, VEGI or TNFSF15) is an anti-angiogenic cytokine. It is an important mediator of inflammation, participates in innate and adaptive immune homeostasis through binding to its receptor, DR3, activating downstream signaling. Numerous studies showed that soluble TL1A can be detected in the serum of patients with T-cell mediated autoimmune diseases like rheumatoid arthritis, psoriatic arthritis, and inflammatory bowel disease. In addition, recent clinical studies suggested that anti-TL1A antibody treatment is a promising therapeutic approach in inflammatory and auto-immune disorders.
Description: Recombinant human TL1A (TNF-like ligand 1A (also known as Vascular endothelial growth inhibitor, VEGI or TNFSF15), encompassing amino acids 72 to 251(end). This construct contains an N-terminal His-tag (6xHis) followed by an Avi-Tag™. This protein was affinity purified. The protein runs as two bands in SDS-PAGE due to variable glycosylation, as confirmed by PNGase treatment.
Format: Aqueous buffer solution.
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Genbank: NM_005118
Host Cell Line: HEK293
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal His-Tag, Avi-Tag™
Uniprot: O95150
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
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