Conjugation: HRP: Horseradish Peroxidase
Description of Target: TMOD3 belongs to the tropomodulin family. It blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.
Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TMOD3
Key Reference: Weber,K.L., J. Cell. Sci. 120 (PT 20), 3625-3632 (2007)
Molecular Weight: 39kDa
Peptide Sequence: Synthetic peptide located within the following region:
LDDLDPENALLPAGFRQKNQTSKSTTGPFDREHLLSYLEKEALEHKDREDProduct Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Protein Name: Tropomodulin-3
Protein Size: 352
Purification: Affinity Purified
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