TMPRSS2 - Vero E6 Recombinant Cell Line

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Applications: This cell line is useful for screening human TMPRSS2 inhibitors.

Background: Human transmembrane serine protease 2 (TMPRSS2) is an enzyme primarily expressed by endothelial cells across the respiratory and digestive tracts. It is involved in viral entry and spread of coronaviruses including SARS-CoV-2, the virus that causes COVID19. Blocking TMPRSS2 could potentially be an effective clinical therapy for COVID-19.

Description: Recombinant clonal stable Vero E6 cell line constitutively expressing full length human TMPRSS2, Genbank #NM_005656.4.

Genbank: NM_005656.4

Host Cell Line: VeroE6

Mycoplasma Testing: This cell line has been screened using the MycoAlert™ Mycoplasma Detection Kit (Lonza, #LT07-118) to confirm the absence of Mycoplasma contamination.

Storage Stability: Store in liquid nitrogen immediately upon receipt.

Supplied As: Each vial contains ~ 2 x 10^6 cells in 1 ml of 10% DMSO in FBS.

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: BSL-1

• SKU: BPS78081
• Manufacturer: BPS Bioscience
• Manufacturer SKU: 78081
• Package Unit: 2 vials
• Quantity Unit: PAK
• Host: Mammalian